副系主任的話
張玉喆 副系主任 |
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歡迎大家來到長庚醫學系,和我們一起學習、生活以及圓夢。醫師始終都是令人尊敬的職業,隨著醫學知識不斷更新,病人照顧模式也必須與時俱進,社會對醫學生將來的醫學專業能力的期許就更高了,這是一個挑戰,也是各位和所有醫學系師長共同的目標,如何幫助大家具備醫學專業素養,從學校教育到臨床場域的病人照護,能展現出符合期待的能力進展,這是需要大家共同努力的。未來幾年的學習,必定是需要跨領域,也需要很好的溝通能力及領導力,這將是各位建構專業認同的關鍵時期,讓各位了解自己在醫師工作的價值與信仰,以及在醫學社群及社會上所扮演的角色,這將是支持各位實現夢想的力量。不論學習、生活、人際關係及臨床工作上,如果遭遇到挑戰,我鼓勵大家一定要正向思考,勇於面對,系上有很多師長都是各個專業領域的典範,能夠引導大家走在正確的方向,系上也還有很多資源能夠協助大家克服困難,美好的未來就在不遠處。 |
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現職/學歷/經歷 |
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現職 長庚大學醫學系副系主任 林口長庚醫院急診醫學科副科主任 長庚醫學教育研究中心副主任 學歷 國立陽明大學醫學系學士 國立陽明大學急重症醫學研究所碩士 澳洲福林德斯大學(Flinders University)臨床教育碩士 經歷 1999~2002 台北榮總兒童醫學部住院醫師 2002~2005 台北榮總急診醫學部住院醫師 2005~迄今 林口長庚醫院急診醫學部主治醫師 2006~2010 急診醫學會教育委員會委員 2010~2016 急診醫學會檢傷工作小組委員 2011~迄今 林口長庚醫院專責教學主治醫師 2012~2016 急診醫學會急診學習里程碑委員會員 2012~2017 長庚大學醫學系專任助理教授 2014~2019 林口長庚醫院臨床技能中心主任 2016~迄今 急診醫學會兒童急症委員會主任委員 2017~迄今 長庚大學醫學系專任副教授 |
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專長與研究領域 |
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專長 急診醫學、兒童急診醫學、醫學教育、高擬真情境模擬教學 研究領域 兒童檢傷分類、急診管理、迷你臨床演練、專業認同與復原力、擬真教學、選科決策、性別議題 |
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期刊論文(近5年) |
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研究計畫 |
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計畫主持人
計劃共同主持人
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專書章節著作 |
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曾獲得之學術獎勵 |
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林蔚然 副系主任 |
得天下英才而教之是人生一大樂事,很高興能成為醫學系師長的一員。我的工作是協助校長,院長,系主任及大學同仁推動醫學系的運作及革新。希望長庚醫學系學生的求學時光,除了學習到豐富的知識外,也能擁有快樂的大學生活,找到自己人生的方向。 |
現職/學歷/經歷 |
現職 長庚大學 醫學系 副系主任 林口長庚醫院 胃腸肝膽科系 教授 學歷 中國醫藥大學 醫學系 學士 英國倫敦大學 瑪莉皇后學院 分子生物醫學博士 經歷 2000-2005 林口長庚醫院內科部住院醫師及胃腸肝膽科系總醫師 2005-迄今 林口長庚醫院胃腸肝膽科系主治醫師 2008-2011 林口長庚醫院胃腸肝膽科系講師 2011-2015 林口長庚醫院胃腸肝膽科系助理教授 2013-2017 長庚大學醫學系助理教授 2015-2020 林口長庚醫院胃腸肝膽科系副教授 2018-2020 內科醫學會學習里程碑委員 2013-迄今 林口長庚醫院內科部PGY副負責人 2016-迄今 林口長庚醫院胃腸肝膽科系研究中心主任 2017-迄今 長庚大學醫學系副教授 2020-迄今 林口長庚醫院內科部整合醫學發展小組負責人 2020-迄今 長庚大學醫學系副系主任 2020-迄今 林口長庚醫院胃腸肝膽科系教授 |
專長與研究領域 |
專長 胃腸肝膽疾病之診療,胃鏡大腸鏡及息肉切除,減重內視鏡操作。 醫學教育,整合醫學。 研究領域 消化道幹細胞,粒線體,能量代謝及癌症相關基礎研究。 |
期刊論文(近5年) |
1. Wang HW, Kuo CJ, Lin WR, Hsu CM, Ho YP, Lin CJ, Su MY, Chiu CT*, Wang CL, Chen KH. The clinical characteristics and manifestations of cytomegalovirus esophagitis. Dis Esophagus. 2016 May;29(4):392-9 2. Alison MR*, Lin WR.(Co-first) Diverse routes to liver regeneration. J Pathol. 2016 Feb;238(3):371-4. 3. Alison MR*, Lin WR. Hepatocytes come out of left field. Hepatology. 2016 Mar;63(3):1041-3. 4. Huang YH, Tseng YH, Lin WR, Hung G, Chen TC, Wang TH, Lee WC, Yeh CT. HBV polymerase overexpression due to large core gene deletion enhances hepatoma cell growth by binding inhibition of microRNA-100. Oncotarget. 2016 Feb 23;7(8):9448-61. 5. Wang HW, Kuo CJ, Lin WR, Hsu CM, Ho YP, Lin CJ, Su MY, Chiu CT*, Chen KH. Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan. Medicine (Baltimore). 2016 Apr;95(14):e3187. 6. Lin WR, Chiang JM, Liang KH, Lim SN, Lai MW, Tsou YK, Hsieh TY, Hsu CK, Yeh CT*. GALNT14 Genotype Predicts Postoperative Outcome of Stage III Colorectal Cancer With Oxaliplatin as Adjuvant Chemotherapy. Medicine (Baltimore). 2016 Apr;95(17):e3487. 7. Lin WR*, Lim SN, Yen TH, Alison MR. The Influence of Bone Marrow-Secreted IL-10 in a Mouse Model of Cerulein-Induced Pancreatic Fibrosis. Biomed Res Int. 2016;2016:4601532. 8. Chen YC, Tseng YC, Huang WH, Hsu CW, Weng CH, Liu SH, Yang HY, Chen KH, Chen HL, Fu JF, Lin WR, Wang IK, Yen TH*. Acute Kidney Injury Predicts Mortality after Charcoal Burning Suicide. Sci Rep. 2016 Jul 19;6:29656. 9. Alison MR*, Lin WR. Regenerating the liver: not so simple after all? F1000Res. 2016 Jul 26;5. pii: F1000 Faculty 10. Lai MW, Liang KH, Lin WR, Huang YH, Huang SF, Chen TC, Yeh CT*. Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation. Oncogenesis. 2016 Dec 5;5(12):e273. 11. Lai MW, Lin TY, Liang KH, Lin WR, Yeh CT*. Hepatitis B viremia in completely immunized individuals negative for anti-hepatitis B core antibody. Medicine (Baltimore). 2016 Dec;95(49):e5625. 12. Huang CL, Wu CH, Chen TH, Lin WP, Sung CM, Kuo CJ, Chen CW, Lin WR, Ho YP, Lin CJ, Hsu CM*, Su MY, Chiu CT. Recurremt bleeding of colonic diverticular hemorrhage after endoscopic treatment: clinical experience of an endoscopic center. Advances in Digestive Medicine (2017) 4, 94-98 13. Li HT, Wu T, Lin WR, Tseng WJ, Chang CW, Cheng MY, Hsieh HY, Chiang HI, Lee CH, Chang BL, Lim SN*. Clinical correlation and prognostic implication of periodic EEG patterns: A cohort study. Epilepsy Res. 2017 Mar;131:44-50. 14. Tsai AI, Hong HH, Lin WR, Fu JF, Chang CC, Wang IK, Huang WH, Weng CH, Hsu CW, Yen TH*. Isolation of Mesenchymal Stem Cells from Human Deciduous Teeth Pulp. Biomed Res Int. 2017;2017:2851906. 15. Yeh CT*, Liang KH, Chang ML, Hsu CW, Chen YC, Lin CL, Lin WR, Lai MW. Phenotypic and Genotypic Shifts in Hepatitis B Virus in Treatment-Naive Patients, Taiwan, 2008-2012. Emerg Infect Dis. 2017 May;23(5):820-821. 16. Tsou YK, Liang KH, Lin WR, Chang HK, Tseng CK, Yeh CT*. GALNT14 genotype as a response predictor for concurrent chemoradiotherapy in advanced esophageal squamous cell carcinoma. Oncotarget. 2017 Apr 25;8(17):29151-29160. 17. Le PH, Liang KH, Chang ML, Hsu CW, Chen YC, Lin CL, Lin WR, Lai MW, Yeh CT*. Clinical Predictors for Neutrophil-to-Lymphocyte Ratio Changes in Patients with Chronic Hepatitis B Receiving Peginterferon Treatment. In Vivo. 2017 Jul-Aug;31(4):723-729. 18. Le PH, Lin WR, Kuo CJ, Wu RC, Hsu JT, Su MY, Lin CJ, Chiu CT*. Clinical characteristics of cytomegalovirus colitis: a 15-year experience from a tertiary reference center. Ther Clin Risk Manag. 2017 Dec 15;13:1585-1593. 19. Lin WR, Hsu CW, Yeh CS, Chen YC, Chang ML. Liang KH, Lin CC, Chu YD, Yeh CT*. Combinations of single nucleotide polymorphisms WWOX-rs13338697, GALNT14-rs9679162 and rs6025211 effectively stratify outcomes of chemotherapy in advanced hepatocellular carcinoma. Asia-Pac J Clin Oncol. 2017;1–10. 20. Weng CH, Chen HH, Hu CC, Huang WH, Hsu CW, Fu JF, Lin WR, Wang IK, Yen TH*. Predictors of acute kidney injury after paraquat intoxication. Oncotarget. 2017 May 18;8(31):51345-51354. 21. Yeh CS, Hsu CW, Liang KH, Chen YC, Lin CL, Chien RN, Hu TH, Lin WR, Lai MW, Chu YD, Yeh CT*. Development of a fibrosis index including hepatitis B virus basal core promoter A1762T mutation for pretherapeutic evaluation. J Gastroenterol Hepatol. 2018 Aug;33(8):1530-1537 22. Alison MR*, Lin WR. (Co-first) Macrophages come on tap for liver fibrosis therapy. Hepatology. 2018 Sep;68(3):1194-1196. 23. Lai MW, Hsu CW, Lin CL, Chien RN, Lin WR, Chang CS, Liang KH, Yeh CT*. Multiple doses of hepatitis B recombinant vaccine for chronic hepatitis B patients with low surface antigen levels: a pilot study. Hepatol Int. 2018 Sep;12(5):456-464. 24. Chen TH, Lin WR*, Lee C, Chiu CT, Hsu JT, Yeh TS, Lin KH, Le PH, Yeh CT*. Prognostic Stratification of Advanced Gastric Signet Ring Cell Carcinoma by Clinicopathological Factors and GALNT14 Genotype. J Cancer. 2018 Sep 8;9(19):3540-3547. 25. Alison MR*, Lin WR. Bile ductular reactions in the liver: similarities are only skin deep. J Pathol. 2019 Jul;248(3):257-259. 26. Li HT, Lee CH, Wu T, Cheng MY, Tseng WJ, Chang CW, Hsieh HY, Chiang HI, Lin CY, Chang BL, Lin WR, Lim SN*. Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study. Neurocrit Care. 2019 Oct;31(2):329-337. 27. Alison MR*, Lin WR. Periportal SRY (Sex Determining Region Y)-Box 9-Positive Hepatocytes: Progenitors With a Biliary Leaning. Hepatology. 2019 Oct;70(4):1470-1473 28. Lin WR*, Chiang JM, Lim SN, Su MY, Chen TH, Huang SW, Chen CW, Wu RC, Tsai CL, Lin YH, Alison MR, Hsieh SY, Yu JS, Chiu CT, Yeh CT. Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas. EBioMedicine. 2019 Jun;44:334-345. 29. Chen CW, Chiu CT, Su MY, Lin CJ, Hsu CM, Lim SN, Yeh CT, Lin WR*. Factors associated with polyp detection during colonoscopy: A retrospective observational study. Kaohsiung J Med Sci. 2019 Sep;35(9):572-577. 30. Lee KC, Lin CL, Hsu CW, Chang ML, Chen YC, Lin WR, Lai MW, Lin KH, Chao M, Chien RN, Yeh CT*. Decreasing seroprevalence of anti-hepatitis D virus antibodies in the antiviral era with inverse association with hepatitis B virus DNA, Taiwan, 2006 to 2019. J Med Virol. 2019 Aug 30. doi: 10.1002/jmv.25582. 31. Chiang CC, Yeh CT, Hwang TL, Chu YD, Lim SN, Chen CW, Kuo CJ, Le PH, Chen TH, Lin WR*. The GALNT14 genotype predicts postoperative outcome of pancreatic ductal adenocarcinoma. J Clin Med 2019, 8, 2225; doi:10.3390/jcm8122225 32. Li HT, Wu T, Lin WR, Lim SN*. Response to "Cefepime-Induced Encephalopathy: A Possible Additional Mechanism of Neurotoxicity". Neurocrit Care. 2020 Apr;32(2):642. 33. Lin WR, Yeh CT*. GALNT14: An Emerging Marker Capable of Predicting Therapeutic Outcomes in Multiple Cancers. Int J Mol Sci. 2020 Feb 21;21(4):1491. 34. Huang HC, Lin WR*, Lim SN, Yeh CT, Yen TH, Alison MR, Chen CS*. (Co-corresponding) Aldolase Triggers Metabolic Reprogramming in Colorectal Cancer in Hypoxia and Stiff Desmoplastic Microenvironments. Colloids Surf B Biointerfaces. 2020 Jun;190:110969. 35. Chu YD, Lin WR, Lin YH, Kuo WH, Tseng CJ, Lim SN, Huang YL, Huang SC, Wu TJ, Lin KH, Yeh CT*. (Co-first) COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma. Cancers (Basel). 2020 Jun 22;12(6):E1646. 36. Liang KH, Cheng ML, Lo CJ, Lin YH, Lai MW, Lin WR, Yeh CT*. Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study. Sci Rep. 2020 Jul 2;10(1):10926. 37. Kuo CJ, Lin CY, Le PH, Chang PY, Lai CH, Lin WR, Chang ML, Hsu JT, Cheng HT, Tseng CN, Lin CJ, Su MY, Hsieh SY, Chiu CT*. Rescue therapy with rifabutin regimen for refractory Helicobacter pylori infection with dual drug-resistant strains. BMC Gastroenterol 2020 Jul 10;20(1):218. 38. Chen CW, Kuo CJ, Chiu CT, Su MY, Lin CJ, Le PH, Lim SN, Yeh CT, Alison MR, Lin WR*. The effect of prophylactic hemoclip placement and risk factors of delayed post-polypectomy bleeding in polyps sized 6 to 20 millimeters: a propensity score matching analysis. BMC Gastroenterol. 2020 Sep 22;20(1):309. |
研究計畫 |
計畫主持人 1. CMRP: CMRPG370721&0722 03/01/2008-02/28/2010 The role of bone marrow stem cell in pancreatic fibrosis and therapeutic effect. 2. NMRP: NMRPG3A0201 08/01/2011-07/31/2012 Tracing stem cell lineages in human gastrointestinal epithelial tumors and tissues. 3. CMRP: CMRPG3A0921~ 0923 01/10/2011-30/09/2014 The role of mitochondrial function and mitochondrial DNA mutation in liver cancer stem cells and hepatocellular carcinoma. 4. CMRP: CMRPG3B0471 02/01/2012-31/03/2013 To evaluate the anti-fibrotic effect of G-CSF through BM stem cell mobilisation and engraftment in a mouse model of pancreatic fibrosis 5.NMRP: NMRPD1B1601~ 1602 08/01/2012-07/31/2014 The role of mitochondrial function and DNA mutation in chronic hepatitis B 6. CMRP: CMRPG3B0801~ 0803 10/01/2012-03/31/2016 The role of mitochondrial function and mitochondrial DNA mutation in colon polyps and colorectal cancer stem cell 7. 跨世紀醫療促進基金會: SMRPG3C0011 04/15/2013-10/31/2014 To evaluate the anti-fibrotic effect of induced pluripotent stem cells in a mouse model of pancreatic fibrosis 8. NMRP: NMRPD1D0491 08/01/2014-07/31/2015 The role of mitochondrial function and DNA mutation in colorectal carcinogenesis 9. CMRP: CMRPG3E1461 06/01/2015~05/31/2016 To evaluate the anti-fibrotic effect of desacyl ghrelin in a mouse model of pancreat fibrosis 10. CMRP: CMRPG3E2181 12/01/2015~04/30/2017 The role of mitochondria function and DNA mutation in colorectal carcinogenesis (2nd and 3rd years) 11. CMRP: CMRPG3F1401 ~1403 06/01/2016~07/31/2019 To use tumor-specific mitochondrial DNA mutations in hepatocellular carcinoma as a personalized serum biomarker for identifying tumor recurrence 12. CMRP: CMRPG3F0061 ~0063 08/01/2016~07/31/2019 The defects of cytochrome c oxidase may contribute to liver cancer recurrence and metastasis through increasing Ras/MAPK pathway 13. CORP: CORPG3F0241 12/01/2016~11/30/2017 The comparison of colonscopic quality between patients with deep sedation and patients with clear consciousness 14. CORP: CORPG3G0501 10/01/2017~05/31/2019 The correlation between post-polypectomy bleeding and prophylactic hemoclip application 15. CMRP: CMRPG3H0241 01/01/2018~12/31/2018 The interconnection of metabolisms, extracellular matrix and mechanotransduction in colorectal cancer 16. NMRP: NRRPG3H0011 08/01/2018-10/31/2019 The association between prognosis and bioenergetic alterations of colon mucosa, polyps and colorectal cancers 17. CORP: CORPG3H0161 10/01/2018~06/30/2020 The Association between Clinical presentation of Small Intestinal Tumor and Prognosis 18. CORP: CORPG3I0011 01/01/2019~12/31/2019 The correlations between microenvironment rigidity and bioenergetic alteration on colorectal cancer 19. CMRP: CMRPG3J0691 08/01/2019~07/31/2020 The role of aldolase, fructose-bisphosphate B and solute carrier family 16 member 4 in colorectal cancer 20. CORP: CORPG3J0501 10/01/2019~09/30/2020 The use of clopidogrel, low-dose aspirin and proton pump inhibitor in reducing the risk of colorectal cancer. 21. NMRP: NRRPG3K0061 08/01/2020~07/31/2021 To study the mechanisms of how the behaviors of hepatocellular carcinoma are controlled by the core subunit of oxidative phosphorylation, and the feasibility of using proteins of the downstream pathway as cancer target therapy. |
曾獲得之學術獎勵 |
跨世紀醫療促進基金會 醫學研究獎 2012 第22屆歐洲聯合消化系醫學周 傑出論文壁報獎2014 林口長庚醫院 優良教師 2014 美國消化系學會 榮譽院士 (Fellow of AGA) 2017 林口長庚醫院 優良服務人員 2018 台灣消化系醫學會年會 優秀論文壁報獎第一名2020 林口長庚醫院 優秀論文獎 2019,2020 林口長庚醫院 資深優良教師 2020 |